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THYROID HORMONE NUCLEAR RECEPTORS IN SKELETAL MUSCLE AS INFLUENCED BY ENVIRONMENTAL TEMPERATURE AND ENERGY INTAKE
Author(s) -
Dauncey M. J.,
Ingram D. L.,
Brown D.,
Hayashi M.
Publication year - 1988
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1988.sp003131
Subject(s) - medicine , hormone , endocrinology , receptor , thyroid , thyroid hormone receptor , nuclear receptor , hormone receptor , litter , biology , adaptation (eye) , thyroid hormones , thyroid hormone receptor beta , thyroid hormone receptor alpha , skeletal muscle , chemistry , ecology , biochemistry , gene , cancer , breast cancer , transcription factor , neuroscience
Young litter‐mate pigs were kept at either 10 or 35 °C and fed either a high (H) or a low (L) food intake producing four groups: 10 H, 10 L, 35 H and 35 L. The numbers of receptors for thyroid hormone in the nuclei of skeletal muscle were estimated and found to be greatest in the 35 H group and least in the 10 L group. The numbers of receptors in the 10 H and 35 L groups were similar and took intermediate values. It is suggested that the differences in receptor numbers represent an adaptation which regulates the tissue response to thyroid hormone. Some possible consequences of this adaptation are discussed.