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THE ULTRASTRUCTURE OF FROG MICROVESSELS FOLLOWING PERFUSION WITH THE IONOPHORE A23187
Author(s) -
Clough Geraldine,
Michel C. C.
Publication year - 1988
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1988.sp003109
Subject(s) - ionophore , ultrastructure , perfusion , anatomy , microcirculation , biophysics , chemistry , calcium , biology , medicine
The ultrastructure of frog mesenteric capillaries and venules has been examined after the permeability of these vessels to fluid and macromolecules has been increased to a measured extent by perfusion with the ionophore A23187. An average 4·5‐fold increase in hydraulic permeability in thirteen vessels was associated with the presence of gaps between the endothelial cells and marked attenuation of endothelial cytoplasm with the appearance of many fenestrations. The changes in ultrastructure suggested much larger increments in permeability than had been measured in these same vessels in vivo .