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EFFECT OF VERATRIDINE INJECTED INTO THE AORTIC ROOT ON RESISTANCE AND CAPACITANCE IN THE ABDOMINAL CIRCULATION IN ANAESTHETIZED DOGS
Author(s) -
Hainsworth R.,
McGregor K. H.,
Ford R.
Publication year - 1986
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1986.sp003019
Subject(s) - veratridine , capacitance , carotid sinus , medicine , anesthesia , vascular resistance , stimulation , cardiology , blood pressure , materials science , chemistry , electrode , sodium channel , metallurgy , sodium
In dogs anaesthetized with chloralose, cardiac receptors were stimulated by injections of veratridine into the aortic root and the effects studied on resistance and capacitance in the vascularly isolated and perfused abdominal circulation. Unless carotid sinus pressure was high, veratridine injections consistently resulted in dilatation of resistance and capacitance vessels. However, at high carotid pressures, the resistance response to veratridine was inhibited and the capacitance response was usually reversed. These results indicate that stimulation of cardiac receptors can affect resistance and capacitance in the abdominal circulation. Further experiments are required to evaluate the physiological role of these responses.