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CONVERTING‐ENZYME INHIBITION AND 1‐SARCOSINE‐8‐ISOLEUCINE‐ANGIOTENSIN II: EFFECTS ON RENAL FUNCTION IN THE DEHYDRATED SHEEP
Author(s) -
Yesberg Nancy E.,
Henderson Myrna,
Dallemagne Catherine,
Law Sandra,
Hamilton D.,
Cross R. B.
Publication year - 1984
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1984.sp002774
Subject(s) - captopril , chemistry , endocrinology , medicine , filtration fraction , effective renal plasma flow , angiotensin converting enzyme , renal function , angiotensin ii , bradykinin , reabsorption , renin–angiotensin system , plasma renin activity , agonist , renal blood flow , blood pressure , receptor , kidney , biochemistry
The effect of a converting‐enzyme inhibitor (captopril) was studied in nine conscious dehydrated Merino ewes. Captopril (4 mg I.V. over 40 min) caused significant decreases in mean arterial blood pressure (M.A.B.P.), renal vascular resistance (R.V.R.) and filtration fraction, and increases in urine flow ( V ), sodium excretion, glomerular filtration rate (G.F.R.), renal plasma flow, solute clearance ( C osm ), solute‐free water reabsorption ( T C,H2O ) and plasma renin activity (P.R.A.). None of these effects was observed when captopril was similarly administered to sheep pretreated with angiotensin II (AII) receptor blocker, l‐sarcosine‐8‐isoleucine‐AII (sarileucin). It is concluded that the effects of captopril were probably not due to bradykinin potentiation but rather to decreased levels of circulating AII. The effect of sarileucin itself was complex. It effectively blocked the pressor response to administered AII, but it also had an AII‐like effect indicated by a rise in R.V.R., and decreases in V, G.F.R., C osm and T C,H2O . This apparent mixture of All agonist and antagonist properties probably accounts for the absence of any change in M.A.B.P. or P.R.A. during sarileucin administration.