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AN INVESTIGATION INTO SOME CEREBRAL MECHANISMS INVOLVED IN SCHEDULE‐INDUCED DRINKING IN THE PIG
Author(s) -
Stephens D. B.,
Ingram D. L.,
Sharman D. F.
Publication year - 1983
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1983.sp002755
Subject(s) - saralasin , polydipsia , water intake , thirst , angiotensin ii , medicine , renin–angiotensin system , endocrinology , ingestion , sed , chemistry , blood pressure , diabetes mellitus
When pigs were fed small amounts at regular short intervals (5–10 min), drinking followed each ingestion. This resulted in a greatly increased total water intake (schedule‐induced polydipsia: s.i.p.). Injection of angiotensin II into the lateral cerebral ventricle of water‐replete pigs on normal feeding also produced a significant increase in water intake. Prior administration of the angiotensin II antagonist, saralasin, attenuated the dipsogenic effect of angiotensin II, but did not modify s.i.p. The tranquillizing drug, azaperone, had no effect on normal water intake and did not modify the response to angiotensin II. However, azaperone reduced the water intake of animals on scheduled feeding. From this, it was concluded that the increased drinking due to scheduled feeding did not involve the renin‐angiotensin system but it is tentatively suggested that it may involve central dopaminergic neuronal systems.