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SEROTONIN, AND MOUSE SPINAL NEURONES IN CELL CULTURE
Author(s) -
Green K. A.,
Cottrell G. A.
Publication year - 1983
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1983.sp002728
Subject(s) - serotonin , neuroscience , psychology , medicine , receptor
Two different responses to serotonin have been observed. One response was a depolarization accompanied by a decrease in membrane conductance. This response was enhanced at depolarized potentials and reduced at hyperpolarized potentials; the apparent conductance change was also reduced at hyperpolarized potentials indicating some voltage sensitivity of the response. The other response was a depolarization accompanied by an increased membrane conductance. The response was enhanced at hyperpolarized potentials and reversed to a hyperpolarization at −35 to −60 mV. The total number of responsive neurones was small (5%). This might be explained by a deficiency of serotonergic input to the recorded cells, since it was shown autoradiographically that very few neurones in the cultures used exhibited a specific high‐affinity uptake for the transmitter, and hence probably contained it.