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GLUCAGON AND ALANINE‐INDUCED INCREASES OF THE CANINE RENAL GLOMERULAR FILTRATION RATE
Author(s) -
Palmore William P.
Publication year - 1983
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1983.sp002727
Subject(s) - medicine , endocrinology , glucagon , chemistry , renal function , somatostatin , renal blood flow , alanine , urea , amino acid , hormone , biochemistry
Renal responses to intravenous DL‐alanine (ala) and glucagon (GLN) infusions were compared in conscious dogs. Doses of GLN (0·1 µg/min) that did not increase plasma glucose (PG) concentrations, a physiological effect of GLN, stimulated glomerular filtration rate (G.F.R.). Higher GLN infusion rates (1·0 and 10·0 µg/min) stimulated G.F.R., renal plasma flow (R.P.F.), PG, and potassium and urea clearances. Ala infusions (1·3 mmol/min) had similar effects if the dogs had been pre‐conditioned by feeding of corn starch, but not if they had been fed a normal diet. This level of ala infusion increased plasma a amino nitrogen to levels equivalent to plasma ala levels reported to stimulate GLN secretion. The reason for the lack of responsiveness to ala infusion when the normal diet was fed was not clear. When somatostatin (3·8, µg/min), an inhibitor of GLN secretion, and ala were infused simultaneously, G.F.R. was lower than when ala alone was infused. The data suggested that the ala‐induced renal effects were mediated by GLN.