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EFFECTS OF ADRENALINE AND NORADRENALINE ON GLUCOSE‐INDUCED ELECTRICAL ACTIVITY OF MOUSE PANCREATIC β CELL
Author(s) -
Santana De Sa Sonia,
Ferrer Rosa,
Rojas Eduardo,
Atwater Illani
Publication year - 1983
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1983.sp002716
Subject(s) - phentolamine , endocrinology , medicine , chemistry , intracellular , tetraethylammonium , hyperpolarization (physics) , inhibitory postsynaptic potential , receptor , membrane potential , potassium , biology , biochemistry , stereochemistry , organic chemistry , nuclear magnetic resonance spectroscopy
The effects of adrenaline and noradrenaline on membrane potential and glucose‐induced electrical activity were studied in micro‐dissected mouse Islets of Langerhans. Both catecholamines induced hyperpolarization and blocked electrical activity in the presence of 11·1 mM glucose. Phentolamine, but not propranalol, blocked these effects, indicating predominantly α receptor action. Quinine, but not tetraethylammonium ions, antagonized the inhibitory effects of the catecholamines. The data are consistent with the hypothesis that α receptor activation induces a transient increase in intracellular Ca 2+ concentration which in turn leads to an increase in K + permeability.