β CELL MEMBRANE POTENTIAL AND INSULIN RELEASE; ROLE OF CALCIUM AND CALCIUM: MAGNESIUM RATIO | Zendy

Atwater Illani | Zendy; Frankel Barbara J. | Zendy; Rojas Eduardo | Zendy; Grodsky Gerold M. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

β CELL MEMBRANE POTENTIAL AND INSULIN RELEASE; ROLE OF CALCIUM AND CALCIUM: MAGNESIUM RATIO

Author(s) -

Atwater Illani,

Frankel Barbara J.,

Rojas Eduardo,

Grodsky Gerold M.

Publication year - 1983

Publication title -

quarterly journal of experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0144-8757

DOI - 10.1113/expphysiol.1983.sp002715

Subject(s) - calcium , insulin , endocrinology , medicine , chemistry , extracellular , magnesium , islet , biophysics , biology , biochemistry , organic chemistry

Glucose‐induced insulin release from perfused rat pancreas was compared with glucose‐induced changes in membrane potential of β cells from mouse islets. Extracellular concentrations of Ca and Mg were varied as steps, simultaneously or separately, from 10% to 200% of normal in the presence of 11·1 mM glucose. A change in Ca induced a transient change in electrical activity paralleled by a transient change in insulin release. If the Ca/Mg ratio was maintained, steady‐state insulin release remained constant between 10% and 200% Ca, while electrical activity showed alterations. Analysis of burst parameters indicated that increased or decreased Ca entry was balanced by decreased or increased excitability. It is postulated that the β cell contains a compensator mechanism for the regulation of Ca influx.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research