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ABSORPTION OF INTACT PEPTIDES: STUDIES ON TRANSPORT OF PROTEIN DIGESTS AND DIPEPTIDES ACROSS RAT SMALL INTESTINE IN VITRO
Author(s) -
Gardner Michael L. G.
Publication year - 1982
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1982.sp002682
Subject(s) - peptide , in vitro , small intestine , chemistry , biochemistry , perfusion , absorption (acoustics) , biology , medicine , physics , acoustics
Passage of intact peptides across isolated rat small intestine has been studied during luminal perfusion with partial digests of proteins or with dipeptides. Significant passage of intact peptide does occur, the amount depending upon the luminal concentration. It probably reflects the ‘digestibility’ of the protein or protein digest. Previous studies are discussed and, although intact peptide transport is probably not of major nutritional importance, it is suggested that the pathophysiological significance of this process and of peptidaemia merits further attention.