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EFFECTS OF FASTING AND GLUCAGON ON THE KINETICS OF ACTIVE HEXOSE ABSORPTION ACROSS THE RAT DISTAL ILEUM IN VIVO
Author(s) -
Debnam E. S.
Publication year - 1982
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0144-8757
DOI - 10.1113/expphysiol.1982.sp002678
Subject(s) - in vivo , hexose , ileum , glucagon , endocrinology , medicine , kinetics , chemistry , absorption (acoustics) , biochemistry , biology , insulin , materials science , enzyme , physics , microbiology and biotechnology , quantum mechanics , composite material
The effects of starvation for 1, 2 or 3 d and the administration of glucagon to fed rats on the kinetics of active glucose and galactose absorption across the distal ileum have been determined in vivo . Fasting caused reductions in ‘apparent K t ’ for glucose and galactose transport together with a decrease in J max for glucose but not galactose absorption. Treatment with glucagon produced decreases in K t for the absorption of both hexoses and an increase in J max for glucose absorption. The J max for galactose uptake, however, was unaltered by glucagon administration. Villus size was unaltered by starvation of up to 3 d duration, but significantly decreased by glucagon treatment. The results suggest that chronically elevated plasma glucagon levels may be a factor in the change in kinetics of hexose absorption in the distal ileum evoked by fasting.