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The Role of Cation‐Activated ATPases in Transmitter Release from the Rat Iris
Author(s) -
Reading H. W.,
Isbir Turgay
Publication year - 1980
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1980.sp002495
Subject(s) - atpase , chemistry , intracellular , biophysics , calcium , enzyme , ion pump , iris (biosensor) , biochemistry , ion , biology , organic chemistry , computer security , computer science , biometrics
Release of noradrenaline (NA) from isolated rat iris during perfusion in K + ‐free medium was confirmed. Direct biochemical measurement of different cation‐activated ATPases did not reveal any definite relationship between Na + K + ATPase and NA release. A significant increase in Ca ++ Mg ++ ATPase activity was found on termination of NA release obtained by reintroduction of K+ to the medium. Criticism of the model for studying enzymatic control of transmitter release under physiological conditions is presented. It is suggested that removal of intracellular Ca ++ ions by a calcium pump is directly associated with termination of transmitter release.