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Endometrial Blood Flow in Anaesthetized Sheep as Measured with Krypton‐85 Clearance and Microsphere Techniques
Author(s) -
Fraser I. S.,
Brown B. W.,
Mattner P. E.
Publication year - 1980
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1980.sp002488
Subject(s) - microsphere , krypton , blood flow , biomedical engineering , medicine , anesthesia , chemistry , xenon , engineering , organic chemistry , chemical engineering
Uterine blood flow rates were obtained with a Krypton ( 85 Kr) clearance technique and with radio‐active microspheres in six anaesthetized, non‐pregnant ewes (a total of ten comparisons). 85 Kr was administered, via a catheter, into the abdominal aorta and β‐emissions were detected with a catheter‐type semi‐conductor detector probe situated in the lumen of a uterine horn. In seven instances, the 85 Kr clearance curve had only one component while in the remaining three instances the curves could be resolved into two components. The flow rates derived from the single component curves and the mean flow rates calculated from the curves with two components were of the same order as, and highly correlated with, estimates of capillary blood flow obtained with microspheres for either the caruncles, the inter‐caruncular endometrium or the total endometrium (r=0·832, r=0·822 and r=0·841, respectively, P<0·005). There was no correlation between the flow rates obtained with the 85 Kr technique and estimates of myometrial capillary blood flow obtained with microspheres.