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The Effect of Ammonium Ion Concentration on the Activity of Adenylate Cyclase in Various Rat Tissues in vitro
Author(s) -
Wiechetek Maria,
Breves G.,
Höller H.
Publication year - 1979
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1979.sp002470
Subject(s) - adenylate kinase , ammonium , cyclase , enzyme assay , in vitro , enzyme , chemistry , endocrinology , medicine , ion , biochemistry , biology , organic chemistry
The effects of three different ammonium ion concentrations (0·143; 14·3; 14 3 mmol.l –1 ) on adenylate cyclase activities in liver, muscle, fat and brain tissue in vitro were studied in the rat. At physiological levels, ammonium ions reduced adenylate cyclase activity in liver and fat by about 30%, did not affect enzyme activity in muscle tissue but increased adenylate cyclase activity in brain by 40%. Similar effects were observed at higher ammonium ion concentrations though there were no statistically significant correlations between ammonium ion concentration and the degree of change of enzyme activity.