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Inhibition by Angiotensin II of Some Vasopressin Effects on Renal Function in Sheep
Author(s) -
Yesberg Nancy E.,
Henderson Myrna,
Budtz-Olsen O. E.
Publication year - 1979
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1979.sp002469
Subject(s) - vasopressin , medicine , endocrinology , filtration fraction , reabsorption , renal function , chemistry , angiotensin ii , renal sodium reabsorption , free water clearance , renal physiology , sodium , arginine , renal blood flow , kidney , blood pressure , biochemistry , amino acid , organic chemistry
The effects of intravenous infusions of arginine vasopressin (AVP) alone and with angiotensin II (AII) on renal function were studied in conscious Merino ewes. AVP at 11.5 pmol.min-1 caused an increase in water and electrolyte output which was associated with a rise in glomerular filtration rate (GFR), solute clearance, solute-free water reabsorption and tubular sodium reabsorption. Addition of AII of 100 ng.min-1 generally reversed all of these effects. The filtration fraction, which rose during AVP infusion, increased further when AII was added due to a greater fall in renal plasma flow than in GFR. The diuretic and electrolyte-excreting effects of infused AVP appeared to be brought about by an increase in GFR. It is suggested that this inappropriate effect of AVP, which is secreted in response to water deprivation, could be countered by the simultaneous production of AII.