Premium
THE EFFECT OF INTRAVENOUS HYPERTONIC SALINE INFUSION ON RENAL FUNCTION AND VASOPRESSIN EXCRETION IN SHEEP
Author(s) -
Yesberg Nancy E.,
Henderson Myrna,
BudtzOlsen O. E.
Publication year - 1978
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1978.sp002446
Subject(s) - vasopressin , endocrinology , free water clearance , reabsorption , medicine , urine osmolality , chemistry , plasma osmolality , renal sodium reabsorption , renal function , sodium , urine flow rate , urine sodium , renal physiology , plasma renin activity , excretion , tonicity , hypertonic saline , effective renal plasma flow , renal blood flow , renin–angiotensin system , blood pressure , organic chemistry
Conscious Merino ewes were given an intravenous hypertonic sodium chloride load of 4 mmol. min −1 for 100 min. This resulted in increases in urine flow, sodium and potassium excretion and plasma sodium concentration and osmolality. Urinary vasopressin output and solute‐free water reabsorption increased and plasma renin activity declined. Renal plasma flow and glomerular filtration rate (GFR) rose, as did the solute clearance. The change in urinary osmolality was related to the initial urine osmolality such that when the initial urine osmolality was high the urine became more dilute, and vice versa . Tubular sodium reabsorption increased but the fractional reabsorption rate fell. It is suggested that the increase in GFR was at least partly due to the increase in AVP and that the electrolyte loss can be accounted for by the increase in GFR without necessarily involving AVP or other hormonal effects at the tubular level.