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EFFECTS OF BILE SALTS ON THE MOTOR ACTIVITY OF THE GUINEA‐PIG GALL‐BLADDER IN VITRO
Author(s) -
Rutishauser Sigrid C. B.
Publication year - 1978
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1978.sp002440
Subject(s) - gall , guinea pig , in vitro , chemistry , inhibitory postsynaptic potential , motor activity , sodium , medicine , endocrinology , biology , biochemistry , ecology , organic chemistry
Intra‐luminal pressures were measured in in vitro preparations of the guinea‐pig gall‐bladder Intrinsic tone and spontaneous activity were recorded together with the response of the gall‐bladder to Pancreozymin. The effect of the presence of a variety of conjugated and unconjugated bile salts in the luminal fluid [pH 7·4] was studied. Sodium deoxycholate and sodium chenodeoxycholate had an inhibitory effect on motor activity at concentrations as low as 6·0x10 −6 mol.l −1 Sodium taurocholate at a concentration of 3x10 −3 mol.l −1 promoted regular spontaneous activity. The results are discussed in relation to their possible physiological, pathological and pharmacological implications.