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THE INFLUENCE OF PARATHYROIDECTOMY UPON CALCIUM AND PHOSPHATE HOMEOSTASIS IN ADULT SHEEP
Author(s) -
McIntosh G. H.,
Tomas F. M.
Publication year - 1978
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1978.sp002425
Subject(s) - reabsorption , medicine , endocrinology , secretion , calcium , homeostasis , parathyroidectomy , calcium metabolism , chemistry , excretion , endogeny , stomach , absorption (acoustics) , phosphate , biology , kidney , biochemistry , parathyroid hormone , physics , acoustics
The absorption and secretion of Ca and PO 4 were measured with the use of radioactive isotopes in 4 adult sheep before and after parathyroidectomy. Secretion of Ca and PO 4 into the stomach and intestines was measured separately. Parathyroidectomy resulted in a negative balance for Ca and PO 4 and an accompanying fall in plasma Ca and PO 4 concentrations. In the case of PO 4 this response was attributed primarily to a reduced intestinal absorption, but for Ca increases in urinary exretion and intestinal secretion also contributed significantly. Secretion of PO 4 to the stomach was reduced but endogenous PO 4 excretion in the faeces was unchanged which indicated a reduced reabsorption of secreted PO 4 by the intestines.