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THE EFFECTS OF UREA INFUSION ON GLOMERULAR FILTRATION RATE AND RENAL PLASMA FLOW IN SHEEP FED LOW AND HIGH PROTEIN DIETS
Author(s) -
Ergene N.,
Pickering E. C.
Publication year - 1978
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1978.sp002417
Subject(s) - abomasum , urea , renal function , medicine , low protein diet , endocrinology , high protein diet , saline , chemistry , filtration fraction , protein diet , dietary protein , effective renal plasma flow , renal blood flow , zoology , biology , rumen , biochemistry , body weight , fermentation
Reducing the dietary N intake of sheep resulted in a significant fall in GFR with no change in RPF. Intravenous infusion of urea for 19—46 h had no effect on the high protein diet but on the low protein diet GFR and FF were increased to values approaching those observed on the high protein diet. On the low protein diet GFR was unaffected by infusion of urea for 4 h or of saline alone for 30 h. It is suggested that the observed changes in GFR are associated with changes in the quantity of protein passing to the abomasum and small intestine.