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THE EFFECT OF SECRETIN AND CHOLECYSTOKININ‐PANCREOZYMIN ON THE SECRETION OF BILE IN THE ANAESTHETIZED RABBIT
Author(s) -
Esteller A.,
Lopez M. A.,
Murillo A.
Publication year - 1977
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1977.sp002407
Subject(s) - secretin , cholecystokinin , secretion , medicine , rabbit (cipher) , chemistry , endocrinology , gastric secretion , computer science , receptor , computer security
Effects of secretin and Cholecystokinin‐Pancreozymin (CCK‐PZ) on the secretion of bile in anaesthetized rabbits have been studied. Single injections of secretin (5.0 u.kg ‐1 ) significantly increased the flow of bile irrespectively of whether the cystic duct was free or had been tied. A sustained increase in bile flow could be obtained by the continuous infusion of secretin. Cholecystokinin‐Pancreozymin was effective in increasing the bile flow in doses of 1.0 u.kg ‐1 . Much of the effect could be attributed to contraction of the gallbladder but a significant increase in flow could stills be elicited after ligation of the cystic duct. Our findings strongly suggest that the biliary secretion in rabbits is not as different from the general pattern as has previously been suggested.