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THE EFFECTS OF VASOPRESSIN ON RENAL SODIUM EXCRETION IN PIGS GIVEN INTRAVASCULAR HYPERTONIC SALT LOADS
Author(s) -
Scott D.,
Morton J. J.
Publication year - 1977
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1977.sp002378
Subject(s) - vasopressin , sodium , excretion , medicine , endocrinology , tonicity , chemistry , urine , organic chemistry
Young pigs of about 25–30 kg liveweight were given intravenous infusions of a hypertonic sodium chloride solution (4·6 mol.l –1 ) at rates varying from 2–6 mmol. min –1 . Such infusions resulted in a marked increase in urine flow and in urinary sodium excretion, the size of these increases being proportional to infusion rate. Circulating vasopressin levels were also markedly increased, the size of these increases being the same as those seen in other pigs given exogenous vasopressin in amounts which were shown to increase urinary sodium excretion. This suggests that vasopressin was probably contributing to the increase in renal sodium excretion seen in those pigs given the intravenous salt loads. Further evidence for this was obtained in experiments in which a greater natriuretic response was found to accompany infusion of a hypertonic salt solution into the carotid artery as opposed to the jugular vein and in which it was shown that circulating vasopressin levels were much higher when the solution was given into the artery. Furthermore, addition of exogenous vasopressin to a hypertonic sodium chloride solution greatly increased the amount of sodium excreted during an infusion compared with when the salt solution alone was given.