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DEPOT IRON IN THE RAT LIVER AFTER HYPERTRANSFUSION WITH RAT ERYTHROCYTES
Author(s) -
Zuyderhoudt F. M. J.,
Van Gool J.,
Jörning G. G. A.
Publication year - 1977
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1977.sp002377
Subject(s) - depot , chemistry , geography , archaeology
In the rat liver the deposition of iron was measured after hypertransfusion with rat erythrocytes. The liver iron fractions were studied during four weeks after the hypertransfusions. In the first week the haemosiderin iron fraction increased together with the ferritin iron fraction. Most iron was deposited as ferritin iron. In the last week of the experiments, while the ferritin iron fraction still increased, the haemosiderin iron fraction decreased. At the same time plasma iron was utilized when erythropoiesis, which had been suppressed by the hypertransfusion, recommenced. It is suggested that, under these experimental conditions, liver haemosiderin iron is used in haemoglobin synthesis.