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THE EFFECT OF THE ANIONS, PHOSPHATE AND SULPHATE, ON NORMAL RATES OF EXCRETION OF POTASSIUM IN DOGS
Author(s) -
Baylis Christine,
O'Connor W. J.
Publication year - 1976
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1976.sp002365
Subject(s) - potassium , phosphate , excretion , chemistry , medicine , endocrinology , inorganic chemistry , biochemistry , organic chemistry
Small doses of (NH 4 ) 2 HPO 4 or KH 2 PO 4 by stomach tube caused increase in plasma PO 4 and PO 4 excretion. Above a threshold of 0·8 mmol.l –1 , increase of plasma PO 4 by 0·5 mmol.l –1 caused PO 4 excretion to increase by about 35 µmol.min. –1 After KH 2 PO 4 this relationship was not altered by the concurrent increases in plasma K and K excretion. After doses of (NH 4 ) 2 SO 4 or K 2 SO 4 , excretion of SO 4 was similarly related to plasma SO 4 and was independent of plasma K and K excretion. An effect of PO 4 on K excretion was observed after doses of (NH 4 ) 2 HPO 4 , when increased excretion of PO 4 was accompanied by increased excretion of K without change in plasma K. There was also increased excretion of NH 4 and a small increase in Na excretion. The changes were similar to those produced by (NH 4 ) 2 SO 4 [O'Connor and Summerill, 1976]. KH 2 PO 4 and K 2 SO 4 produced increase in plasma K and increased excretion of K not significantly different from the changes produced by KCI or KHCO 3 [Baylis and O'Connor, 1976]. After KH 2 PO 2 or K 2 SO 4 , the urinary anion was PO 4 or SO 4 , instead of Cl and HCO 3 . Any effect of anions on K excretion was much less than the effect of increase in plasma K. At low rates of excretion of K, increased urinary excretion of impermeant anion can determine increased excretion of K. However, the effect of anion is small in comparison with the effect of increase in plasma K.