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A SEARCH FOR THE FACTORS RESPONSIBLE FOR ABSENCE OF RECOVERY OF THE NORMAL VASCULAR RESPONSE TO OXYTOCIN FOLLOWING SYMPATHETIC NERVE INJURY
Author(s) -
Gillespie J. S.,
Lloyd Sybil,
Pickford Mary
Publication year - 1976
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1976.sp002364
Subject(s) - oxytocin , sympathetic nerve , medicine , neuroscience , psychology , blood pressure
In dogs following crush injury to the lumbar sympathetic trunk, reflex vasoconstriction reappears in 4—6 months but the normal vasodilator response to oxytocin does not return even 12 months after crush. Histochemical examination of the walls of the blood vessels shows that division or crush of the lumbar sympathetic trunk or removal of terminal ganglia leads to decentralization, not denervation of the blood vessels. True denervation follows division or crush of the sciatic and femoral nerves. Following recovery from sciatic or femoral crush the pattern of peripheral innervation appears histochemically normal. However, there is no return of the normal vasodilator response to oxytocin. It is concluded that a normal response to oxytocin does not return even after long‐term recovery from sympathetic injury, nor does its effect depend on a normal pattem of peripheral adrenergic innervation, but on an unknown more central activity of the sympathetic nervous system.