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THE EFFECT OF VASOPRESSIN UPON THE EXCRETION OF CALCIUM BY THE SHEEP
Author(s) -
Beal A. M.,
Clark R. C.,
Cross R. B.,
French T. J.
Publication year - 1976
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1976.sp002342
Subject(s) - calcium , excretion , vasopressin , endocrinology , medicine , potassium , chemistry , sodium , urine flow rate , free water clearance , calcium metabolism , renal physiology , renal function , biology , organic chemistry
Vasopressin (140 µU/min) was infused intravenously into 12 conscious merino ewes for 2 hr. Urine flow rate and free water clearance were consistently reduced. There was no effect upon renal plasma flow, glomerular filtration rate or the rate of excretion of sodium, potassium, magnesium, chloride or phosphate. Although all animals received 75 mmol calcium chloride into the rumen on the previous day, five commenced the experiment with calcium excretion rates of less than 1 µmol/min. In these, vasopressin further decreased calcium excretion. In seven animals with calcium excretion rates between 2 and 20 µmol/min vasopressin had no effect upon either total calcium or free ionized calcium excretion rate.