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THE ACUTE EFFECTS OF INTRAVENOUS INFUSION OF PARATHYROID HORMONE ON URINE, PLASMA AND SALIVA IN THE SHEEP
Author(s) -
Clark R. C.,
French T. J.,
Beal A. M.,
Cross R. B.,
BudtzOlsen O. E.
Publication year - 1975
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1975.sp002307
Subject(s) - saliva , urine , parathyroid hormone , medicine , hormone , intravenous infusions , endocrinology , calcium
Following an intravenous loading injection of 75 U.S.P. Units of Para‐Thor‐Mone (Eli Lilly and Co.), seven conscious, non‐pregnant, non‐lactating Merino ewes were infused with a maintenance dose of the hormone at a rate of 4·75 U.S.P. units/min for 2 hr. The classical hypercalcaemia and hypophosphataemia of the non‐ruminant was observed, but the hypercalcaemia was only small. Plasma potassium concentration decreased, while there were no changes in plasma sodium, chloride or magnesium. The classical phosphaturic effect of the hormone was not observed, only trace amounts of phosphate being excreted throughout the experiment. Urinary excretion of calcium and magnesium decreased, urine flow and urinary excretion of sodium, potassium, chloride, bicarbonate and urine pH increased. Glomerular filtration rate was unaffected, but renal plasma flow increased. The concentration and secretion rate of salivary phosphate increased markedly. Changes in the other important salivary electrolytes (sodium, potassium, chloride, bicarbonate and hydrogen ion) also occurred, but it was difficult to separate primary from secondary effects of the hormone. Saliva flow rate increased transiently following hormone injection, but the effect was not sustained by the maintenance infusion.