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THE INFLUENCE OF PHENTOLAMINE ON THE HYPERGLYCAEMIC AND LIPOLYTIC EFFECTS OF AMMONIA IN SHEEP
Author(s) -
Wiechetek Maria,
Garwacki S.,
Barej W.
Publication year - 1975
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1975.sp002306
Subject(s) - phentolamine , ammonium chloride , ammonia , chemistry , endocrinology , ammonium , stimulation , medicine , lipolysis , metabolism , carbohydrate metabolism , adrenergic , receptor , biochemistry , adipose tissue , biology , organic chemistry
Intravenous infusion over 30 min of ammonium chloride [0·1 g/kg b.w.] caused a significant increase of blood glucose and free fatty acids levels, and a similar effect was observed with adrenaline. Phentolamine [1 mg/kg b.w.] abolished the hyperglycaemic action of ammonium chloride but only slightly diminished the lipolytic effect. It is concluded that the ammonium ion influences carbohydrate metabolism chiefly by way of catecholamines and stimulation of α‐adrenergic receptors, while tissue lipids are mobilized by ammonia by another route, possibly directly.