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LACTOFERRIN IN RABBIT BILE: ITS RELATION TO IRON METABOLISM
Author(s) -
Van Vugt H.,
Van Gool J.,
Ladiges N. C. J. J.,
Boers W.
Publication year - 1975
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1975.sp002305
Subject(s) - lactoferrin , endocrinology , metabolism , medicine , chemistry , mobilization , transferrin , biochemistry , biology , history , archaeology
The relation of biliary lactoferrin concentration and the iron status of the body was studied in normal, anaemic and iron‐loaded rabbits. In anaemic rabbits lactoferrin concentrations rose to two to three times the original values. Loading with iron resulted in a return to normal values. Mobilization of iron with desferrioxamine also gave a rise in lactoferrin concentration in bile. Lactoferrin may have a regulatory function in situations of enhanced iron absorption or mobilization of iron from depots.