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CHANGES IN BLOOD COMPOSITION AND IN URINARY MINERAL EXCRETION IN THE PIG IN RESPONSE TO ACUTE ACID‐BASE DISTURBANCE
Author(s) -
Scott D.,
Mcintosh G. H.
Publication year - 1975
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1975.sp002299
Subject(s) - potassium , chemistry , bicarbonate , excretion , net acid excretion , sodium , calcium , urine , sodium bicarbonate , magnesium , ammonia , hydrochloric acid , medicine , phosphorus , endocrinology , acid–base homeostasis , zoology , biochemistry , inorganic chemistry , biology , organic chemistry
Young pigs (about 25 kg) were given intravenous infusions of hydrochloric acid or sodium bicarbonate to produce acute variations in blood pH. Infusion of acid resulted in increased excretion of calcium, magnesium, sodium, potassium, chloride and ammonia in the urine. The concentrations of potassium and chloride in the plasma were increased while those of calcium and phosphorus were reduced. Infusion of alkali produced few changes in urinary mineral excretion: potassium being increased and ammonia reduced. Changes in the plasma in response to alkali infusion included an increase in sodium concentration and a fall in the concentrations of potassium and chloride. Normal values for blood pH, pCO2 and base excess found in the pigs used in these studies were all higher than those considered to be normal in both man and dog. Renal bicarbonate threshold in the pig was also higher than in those other species in that little or no bicarbonate appeared in the urine until the concentration of bicarbonate in the plasma exceeded 31—32 mmol/l.