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THE MOVEMENT OF AN UNEMULSIFIED OIL TEST MEAL AND AQUEOUS‐AND OIL‐PHASE MARKERS THROUGH THE INTESTINE OF NORMAL AND BILE‐DIVERTED RATS
Author(s) -
Brand S. J.,
Morgan R. G.H.
Publication year - 1975
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1975.sp002285
Subject(s) - meal , chemistry , phase (matter) , small intestine , food science , medicine , gastroenterology , biochemistry , organic chemistry
An unemulsified oil test meal containing aqueous‐ and oil‐phase markers (PEG and 3 H labelled triether) was fed to control and bile fistula rats. PEG moved ahead of the lipid phase in all groups, and was of limited value as a marker for the test meal. Triether was an excellent marker for studies of gastric emptying. An unexpectedly high correlation was seen between the triether and the test meal and its digestion products in the intestine. The results suggest that triether is a valid marker for following the movement of lipid through the bowel under the conditions of this study. Triether/fat ratios indicated that fat absorption occurred largely from the upper small bowel in control animals and from the lower small bowel in the absence of bile. Bile diversion resulted in more rapid gastric emptying initially, but very slow gastric emptying of the last part of the oil test meal. Intestinal transit of test meal or either marker was not significantly affected by bile diversion. No evidence for a direct effect of bile diversion on gastrointestinal motility was found.