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EFFECT OF EXOGENOUS PROGESTERONE ON THE RATES OF UTERINE BLOOD FLOW AND OXYGEN CONSUMPTION OF SHEEP IN EARLY PREGNANCY
Author(s) -
Caton D.,
Abrams R. M.,
Lackore L. K.,
James G.,
Barron D. H.
Publication year - 1974
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1974.sp002265
Subject(s) - uterus , blood flow , pregnancy , gestation , oxygen , endocrinology , medicine , chemistry , biology , genetics , organic chemistry
Progesterone was administered to 33 ewes which were between the 30th and 55th days of gestation, to see if it could change the rate (ml./kg/min) of uterine blood flow. In acute and in chronic experiments, rates were lower in treated animals. Administration of progesterone also appeared to be associated with a diminution in the rate of oxygen consumption (ml./kg/min) of the uterus and its contents. The significance of these observations to the interpretation of differences in rates of uterine blood flow and oxygen consumption which occur in normal pregnancy is discussed.