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THE EFFECTS OF PROSTAGLANDINS E 2 , A 2 AND F 2α ON CAROTID BARORECEPTORS AND CHEMORECEPTORS
Author(s) -
McQueen D. S.,
Belmonte C.
Publication year - 1974
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1974.sp002242
Subject(s) - baroreceptor , chemoreceptor , carotid sinus , carotid bifurcation , medicine , blood flow , carotid body , chemistry , endocrinology , blood pressure , receptor , anesthesia , carotid arteries , heart rate
The actions of prostaglandins E 2 , A 2 and F 2α on the sensory receptors of the carotid bifurcation have been investigated. Electrical activity of baroreceptor and chemoreceptor fibres was recorded from the sinus nerve of anaesthetized cats. Prostaglandins elicited alterations in blood pressure which were accompanied by changes in baroreceptor activity. Chemoreceptor spontaneous activity was modified by the injection of prostaglandins; such variation did not occur in vitro and thus appears to be secondary to changes in carotid blood flow. We have been unable to demonstrate any action of the prostaglandins at the concentrations studied on baroreceptors or chemoreceptors of the carotid bifurcation, apart from changes secondary to vascular effects.