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THE EFFECT OF TETRODOTOXIN ON THE TRANSMEMBRANE POTENTIALS OF THE HEART CELLS
Author(s) -
Nikitopoulou Georgia
Publication year - 1974
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1974.sp002238
Subject(s) - tetrodotoxin , biophysics , transmembrane protein , purkinje fibers , chemistry , medicine , neuroscience , endocrinology , biology , electrophysiology , biochemistry , receptor
The effect of tetrodotoxin on the transmembrane potentials of His‐Purkinje fibres and of myocardial cells in dog hearts has been examined. The Purkinje fibres appeared to be less susceptible to the action of tetrodotoxin than the ventricular cells. Tetrodotoxin 10 –7 g/ml. irreversibly abolished the activity of ventricular cells, but 10 –4 g/ml. was required to affect the production of action potentials in Purkinje fibres. Withdrawal of calcium ions probably facilitated the action of tetrodotoxin on Purkinje fibres.