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FATTY ACID COMPOSITION OF TISSUE LIPIDS IN CHOLINE DEFICIENT RATS
Author(s) -
Chahl J. S.,
Kratzing C. C.
Publication year - 1973
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1973.sp002215
Subject(s) - choline , stearic acid , arachidonic acid , chemistry , oleic acid , triglyceride , medicine , composition (language) , endocrinology , fatty acid , phospholipid , biochemistry , cholesterol , biology , linguistics , philosophy , organic chemistry , membrane , enzyme
Rats fed a choline deficient diet for three weeks had up to 38% of their liver weight in lipids, compared with 6·5% in choline supplemented controls. This large increase in liver lipids was due to an accumulation of triglycerides, whose fatty acid composition was not altered in choline deficiency although the plasma triglyceride concentration of stearic acid was increased and that of oleic acid was decreased. In choline‐deficient rats, the concentration of arachidonic acid was decreased in liver phospholipids while that of docosapolyenoic acids was increased. There were more widespread changes in the cholesterol ester fatty acids of liver and plasma in choline deficient rats. It is proposed that selective impairment of transport of lipid species, depending on fatty acid composition, occurs in choline deficiency.