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THE TIME COURSE OF THE DIURETIC RESPONSE TO LEFT ATRIAL DISTENSION
Author(s) -
Lawrence M.,
Ledsome J. R.,
Mason J. M.
Publication year - 1973
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1973.sp002210
Subject(s) - distension , diuretic , antidiuretic , medicine , endocrinology , excretion , urine osmolality , urine , free water clearance , urine flow rate , hemodynamics , left atrium , chemistry , hormone , atrial fibrillation
Distension of the left atrium for a 30 min period causes an increase in urine flow, osmolal clearance and free water clearance. The present experiments examine in detail the changes in urinary excretion during a 90 min distension of the left atrium. The experiments demonstrate that in anaesthetized dogs when distension of the left atrium is continued for a 90 min period the increases in urine flow, solute excretion, and free water clearance are transient. Urine flow, free water clearance, and urine osmolality returned completely to control values only after release of left atrial distension. In contrast, solute excretion returned to control values 40 min after the start of left atrial distension and was independent of any concurrent changes in the dilution of the urine. The results support the hypothesis that the diuretic response to left atrial distension is dependent upon two mechanisms: a decrease in the rate of release of antidiuretic hormone from the neurohypophysis, which may be prolonged; and a haemodynamic mechanism which under the conditions of the present experiments appears to be short lived.