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THE ACTION OF GASTRIN AND CHOLECYSTOKININ‐RELATED PEPTIDES ON PANCREATIC SECRETION IN THE RAT
Author(s) -
Dockary G. J.
Publication year - 1973
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1973.sp002201
Subject(s) - gastrin , cholecystokinin , pentagastrin , tyrosine , secretion , chemistry , endocrinology , medicine , pancreas , bombesin , peptide , residue (chemistry) , pancreatic polypeptide , biology , biochemistry , gastric acid , neuropeptide , receptor , glucagon , hormone
The responses of the rat pancreas to porcine gastrins I and II and to six synthetic peptides, with structures related to gastrin and cholecystokinin, have been studied. All the peptides stimulated both the rate of flow and rate of protein secretion from the pancreas. The observed and the calculated maximal responses to gastrins I and II, and to pentagastrin and the C‐terminal octapeptide of cholecystokinin, were similar. There were, however, marked differences in potency between the various peptides. Those peptides in which the tyrosine residue was sulphated and was at position 7 from the C‐terminus were considerably more potent in stimulating both flow and protein responses of the pancreas, than those peptides in which the tyrosine was either absent, unsulphated, or at position 6 from the C‐terminus.