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THE EFFECT OF ISOPRENALINE ON THE CARDIAC AND RESPIRATORY RESPONSES TO EXERCISE
Author(s) -
Silverman M.,
Zeidifard E.,
Paterson J. W.,
Godfrey S.
Publication year - 1973
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1973.sp002193
Subject(s) - isoprenaline , stroke volume , cardiac output , respiratory minute volume , ventilation (architecture) , medicine , cardiology , heart rate , bicycle ergometer , respiratory exchange ratio , anesthesia , respiratory system , hemodynamics , blood pressure , stimulation , physics , thermodynamics
The effects of intravenous isoprenaline on the response to exercise were studied in five normal adults. Each subject exercised on a bicycle ergometer at work loads of 50, 100, 150 watts. At each work load ventilation and gas exchange were measured; cardiac output and stroke volume were calculated using the Indirect (CO 2 ) Fick method. Isoprenaline produced no significant changes in oxygen consumption or in minute ventilation. Heart rate was significantly increased by isoprenaline in all subjects, the increment becoming smaller at higher workloads. In four of the subjects cardiac output was increased by isoprenaline, stroke volume being virtually unchanged. In the remaining subject cardiac output was unchanged with a fall in stroke volume.