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RENAL EXCRETION OF POTASSIUM AND POTASSIUM TOLERANCE IN THE PIG
Author(s) -
Mason G. D.,
Scott D.
Publication year - 1972
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1972.sp002175
Subject(s) - potassium , excretion , urine , chemistry , medicine , endocrinology , diuresis , sodium , kidney , renal function , acidosis , renal physiology , metabolic acidosis , net acid excretion , biochemistry , organic chemistry
Young pigs given supplements of KCl in the food excreted the additional KCl in the urine indicating the importance of the kidney in the regulation of potassium excretion. Intravenous infusion of KCl increased the concentration of potassium in the plasma and the rate of excretion of potassium in the urine. This increase was proportional to infusion rate and in some experiments the amount of potassium excreted in the urine exceeded the amount filtered at the glomerulus, demonstrating net secretion of potassium by the renal tubule. Urinary excretion of sodium was markedly increased during KCl infusion. After pigs had been given a diet containing supplementary KCl for 6 days their ability to excrete potassium in the urine in response to intravenous KCl infusion was not altered although the sodium diuresis was much reduced. Intravenous infusion of KCl into acidotic pigs resulted in a rise in the rate of excretion of potassium in the urine of less than half that seen in pigs in normal acid‐base balance given the same rate of infusion. Glomerular filtration rate and the amounts of potassium filtered at the glomerulus during KOl infusion were unaffected by acidosis, which suggests that the lowered excretion of potassium in urine seen in acidotic pigs was the result of reduced tubular secretion.