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THE EFFECT OF ACETYLSALICYLIC ACID ON PLATELET ADHESION IN THE INJURED ABDOMINAL AORTA
Author(s) -
Sheppard B. L.
Publication year - 1972
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1972.sp002165
Subject(s) - platelet , adhesion , platelet adhesiveness , basement membrane , platelet adhesion , chemistry , endothelium , in vitro , abdominal aorta , aorta , platelet rich plasma , agglutination (biology) , anatomy , biophysics , pathology , biochemistry , immunology , medicine , platelet aggregation , biology , surgery , organic chemistry , antigen
The effect of a single oral dose of acetylsalicylic acid (ASA) on platelet adhesion in the rabbit abdominal aorta following a standard mechanical removal of the endothelium has been observed with both the scanning and transmission electron microscopes, in conjunction with studies on the agglutination properties of the platelets in vitro . It was found that the ASA did not prevent adhesion of platelets to the subendothelial surface although they did not appear to be adhering to the exposed collagen fibres but rather to endothelial basement membrane and microfibrils of the internal elastic lamina, often in small clumps. A large number of leucocytes were also observed adhering to the surface denuded to endothelium. The platelets obtained from ASA treated animals were morphologically normal, but unlike platelets obtained before treatment, did not adhere to collagen fibres in vitro; even when ADP was added the platelets adhered to one another but not to the collagen.