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THE EFFECT OF EXERCISE UPON ACETOACETATE METABOLISM IN ATHLETES AND NON‐ATHLETES
Author(s) -
Johnson Ralph H.,
Walton John L.
Publication year - 1972
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1972.sp002139
Subject(s) - ketone bodies , ketosis , athletes , glycerol , medicine , endocrinology , metabolism , physical therapy , zoology , chemistry , biochemistry , biology , diabetes mellitus
Thirteen male subjects at rest took sodium acetoacetate (200 ml., 0·4 M) by mouth and the subsequent changes in blood ketone bodies (acetoacetate plus 3‐hydroxybutyrate), glucose, glycerol and free fatty acids were measured at intervals. Five of the subjects were in a state of athletic training and the others were not. Three of the trained subjects and six of the untrained were then given the same dose of acetoacetate during and again after a 1·5 hr run, and similar measurements made and compared with those during a run without giving acetoacetate. At rest, no difference appeared between the trained and the untrained; but after running, only the untrained showed significant ketosis and a decreased tolerance to acetotacetate. It is concluded that acetoacetate utilisation rises during exercise, and production is well matched to utilization in the athletically trained subject, but is excessive during and after exercise in the untrained subject.