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CONTRACTION OF CHICKEN RECTUM TO NERVE STIMULATION AFTER BLOCKADE OF SYMPATHETIC AND PARASYMPATHETIC TRANSMISSION
Author(s) -
Bartlet A. L.,
Hassan T.
Publication year - 1971
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1971.sp002117
Subject(s) - hexamethonium , phentolamine , bretylium , contraction (grammar) , stimulation , endocrinology , medicine , propranolol , rectum , chemistry , adrenergic , receptor
The longitudinal muscle of an isolated Remak nerve‐rectum preparation from the chicken responded to nerve stimulation with a contraction or, when the tone of the preparation was raised by acetyl‐β‐methylcholine (11·0 mM), with a contraction followed by a relaxation. The relaxation of the preparation was unaffected by hexamethonium, antagonized by bretylium, blocked by a combination of propranolol and phentolamine at specific concentrations and was absent or diminished in reserpinised preparations. The contraction was abolished by hexamethonium or tubocurarine and was partially antagonized by hyoscine.