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RENAL EXCRETION OF ACID AND BASE IN THE PIG
Author(s) -
Scott D.
Publication year - 1971
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1971.sp002116
Subject(s) - excretion , net acid excretion , chemistry , medicine , urine , acidosis , endocrinology , sodium bicarbonate , sodium , metabolic acidosis , titratable acid , potassium , bicarbonate , calcium , renal tubular acidosis , ingestion , biochemistry , organic chemistry
Pigs fed a meal diet excreted between 100 and 200 m‐equiv/day of acid in the urine and about one‐third of this acid was present as titratable acid phosphate and the remainder as ammonium ions. Acidosis, produced by giving NH 4 Cl in the food or infusing HCl intravenously, increased the urinary excretion of acid, and nearly all of this increase appeared as ammonium ions without increased excretion of phosphate. Acidosis also increased urinary excretion of calcium and sodium but excretion of potassium was not affected. Few changes in faecal mineral excretion occurred during acidosis although sodium excretion was reduced. Ingestion of sodium bicarbonate increased urine pH and urinary excretion of bicarbonate but reduced the excretion of calcium in urine. These results suggest that renal control of acid and base excretion in the pig is similar to that in man and the dog.