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THE INFLUENCE OF CHRONIC ADMINISTRATION OF PENTAGASTRIN ON THE RAT PANCREAS
Author(s) -
Mayston P. D.,
Barrowman J. A.
Publication year - 1971
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1971.sp002105
Subject(s) - pentagastrin , gastrin , medicine , cholecystokinin , muscle hypertrophy , endocrinology , pancreas , tetrapeptide , gastrointestinal tract , chemistry , biology , stomach , biochemistry , secretion , peptide , receptor , gastric acid
Chronic administration of pentagastrin to rats results in hypertrophy of the acinar cells of the pancreas. This hypertrophy is accompanied by a decrease in the specific activities of pancreatic enzymes of the tissue in terms of protein content, and an increase in the RNA : DNA ratio of the tissue. An increase in weight of a duodenal segment has also been observed. The suggestion is put forward that the tetrapeptide, Try‐Met‐Asp‐Phe‐NH 2 , the sequence occurring at the carboxyl terminus of gastrin and cholecystokinin, may exert a trophic influence upon several tissues of the upper gastrointestinal tract.