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THE CONTRIBUTION OF EFFUSED BLOOD TO THE PROTEIN CATABOLIC RESPONSE TO FRACTURE
Author(s) -
Campbell Rosa M.,
Cuthbertson D. P.
Publication year - 1970
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1970.sp002086
Subject(s) - catabolism , protein catabolism , medicine , endocrinology , urine , protein metabolism , urinary system , excretion , chemistry , biochemistry , metabolism , amino acid
Although injuries such as fracture of a long bone may lead to the effusion of a considerable amount of blood in the area of trauma, organization of the haematoma can play but a minor role in the increased urinary excretion of nitrogen and other catabolites which constitute the normal response to moderate or severe injuries in the well nourished man or lower animal at normal environmental temperatures (20–22°C) for the following reasons: (1) adrenalectomy but without supporting corticosteroid abolishes the catabolic response; (2) protein deprivation before injury also abolishes it; (3) an environmental temperature of 30°C reduces the normal response; (4) additional non‐protein sources of energy in the diet reduce the catabolic response; (5) infused blood is apparently not rapidly catabolized. If the organization of a haematoma in the fracture site was the main source of the extra nitrogen found in the urine, then conditions 1–4 should likewise have demonstrated the effect. The fact that they did not supports the view that the organization of the haematoma or the presence of infused whole blood play but a relatively small and/or slow part in the characteristic protein catabolic response to fracture.