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MECHANISM OF ANTITREMORINE‐ACTIVITY OF ADRENERGIC BETA‐RECEPTOR ANTAGONISTS IN THE RAT
Author(s) -
Sharma P. L.
Publication year - 1970
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1970.sp002069
Subject(s) - propranolol , chemistry , potency , pharmacology , adrenergic , adrenergic receptor , endocrinology , medicine , receptor , biochemistry , in vitro
The effect of dl‐propranolol, d‐propranolol, dl‐INPEA and d‐INPEA on tremor induced by tremorine (1,4‐dipyrrolidino‐2‐butyne dihydrochloride) was studied in the rat by administration both before and after the tremorine. Hyoscine was used as the standard drug for comparison. Both dl‐propranolol and dl‐INPEA reduced the intensity of tremors. On a weight to weight basis dl‐propranolol was more potent than hyoscine, while dl‐INPEA was less potent than hyoscine. Both d‐propranolol and d‐INPEA had no appreciable effect on the tremorine‐tremor. The anti‐tremor activity is thus related to the potency of these drugs as beta‐receptor antagonists.