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ACTION OF OXYTHIAMINE AND PYRITHIAMINE ON THE ISOLATED RAT SUPERIOR CERVICAL GANGLION
Author(s) -
Perri V.,
Sacchi O.,
Casella C.
Publication year - 1970
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1970.sp002048
Subject(s) - superior cervical ganglion , thiamine , incubation , ganglion , chemistry , medicine , endocrinology , biology , anatomy , biochemistry
Incubation of isolated preparations of the superior cervical ganglion of the rat in the presence of low concentrations of oxythiamine and pyrithiamine results in an early and pronounced decrease of the post‐ganglionic potential. This effect is particularly evident with regard to oxythiamine. The depressant action of both antithiamines on ganglion transmission appears to be specifically due to their metabolic competition because it can be completely prevented by the presence of equimolecular amounts of thiamine in the incubating medium.