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EFFECTS OF ADRENALIN AND ANAPHYLAXIS ON THE AGGREGATION OF THE CELLULAR CONSTITUENTS OF THE BLOOD IN VIVO
Author(s) -
Stehbens W. E.
Publication year - 1969
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1969.sp002003
Subject(s) - anaphylaxis , platelet , microcirculation , epinephrine , in vivo , platelet aggregation , shock (circulatory) , anaphylactic shock , platelet activating factor , medicine , blood flow , immunology , pharmacology , chemistry , allergy , biology , microbiology and biotechnology
The effect of adrenalin and anaphylaxis on the behaviour of leucocytes, erythrocytes and platelets in the microcirculation was observed by means of transparent chambers inserted in rabbits' ears. Within one minute of the intravenous administration of adrenalin, blood flow became more brisk and within 2 to 5 minutes, extensive platelet aggregation and platelet leucocyte microthrombi were observed. After 6 to 7 minutes flow reverted to normal but microthrombi persisted for as long as 30 minutes. Anaphylaxis was induced by the administration of horse serum to sensitized rabbits, the first observable effect upon the injection of the shocking dose being platelet aggregation and the sticking of leucocytes to the vessel wall. Red cells adhered to leucocytes and to one another in aggregates, at times forming distinct sludge before the flow markedly diminished at about 4 minutes. These changes occurred invariably, quite irrespective of the death or survival of the rabbit. Sludging of erythrocytes was universal and so prominent that it appears to be a contributory factor in the production of anaphylactic shock. Adrenalin administration greatly improved the flow in anaphylaxis, but had no direct desludging effect on erythrocyte conglutination.