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CHANGES IN THE ULTRASTRUCTURE OF RAT MYOCARDIUM INDUCED BY HYPOKALAEMIA
Author(s) -
Emberson J. W.,
Muir A. R.
Publication year - 1969
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1969.sp002002
Subject(s) - ultrastructure , myofibril , perfusion , anatomy , chemistry , biophysics , medicine , biology , biochemistry
Changes in the ultrastructure of adult rat ventricular muscle induced by in vitro perfusion with hypokalaemic Krebs‐Ringer solutions are described. In all experiments the [Ca 2+ ] was 1·27 mM./l. After perfusion with [K + ]=0, the myofibrils show severe contractures; after [K + ]=1·19 or 2·5 mM./l. perfusion, disintegration of the thin filaments was shown; disappearance of myofibrillar insertion plaques at the intercalated discs was observed after perfusion with [K + ] ≤ 1·19; with 〉 2·5 mM./l [K + ], normal ultrastructure was retained.