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AUGMENTED RENAL EXCRETION OF CALCIUM AND MAGNESIUM IN SHEEP AFTER FEEDING
Author(s) -
Stacy B. D.
Publication year - 1969
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1969.sp001994
Subject(s) - hypercalciuria , endocrinology , calcium , excretion , medicine , magnesium , chemistry , bicarbonate , urinary system , acidosis , excretory system , metabolic acidosis , acid–base homeostasis , biology , organic chemistry
When penned sheep were given their daily food, there were marked increases in the rate of urinary excretion of calcium and magnesium, and a sharp fall in urinary pH. There were also post‐prandial increases in the plasma levels of calcium and magnesium, and a fall in blood pH and plasma bicarbonate concentration. By analogy with the effects of metabolic acidosis in other species, it seemed likely that the hypercalciuria in the sheep was causally related to the change in acid‐base balance after feeding. It was concluded that the excretory changes reflected the response of the kidney to intercompartmental shifts of body fluid following the potent stimulus to salivary secretion during eating. In these experiments, the excretion of inorganic phosphate was extremely low, and the absence of this urinary buffer was probably an important factor contributing to the abrupt and considerable fall in urinary pH after feeding.