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THE EFFECT OF ENVIRONMENTAL TEMPERATURE ON HEALING OF BONE LESIONS IN THE RAT. II. THE EFFECT OF BONE INJURY ON MINERAL METABOLISM AT 20° C. AND 30° C
Author(s) -
Cuthbertson D. P.,
Tilstone W. J.
Publication year - 1968
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1968.sp001988
Subject(s) - lesion , bone healing , tibia , drill hole , fracture (geology) , bone mineral content , calcium , tracer , tibia fracture , medicine , chemistry , bone mineral , dentistry , anatomy , drill , pathology , osteoporosis , materials science , physics , nuclear physics , composite material , metallurgy
Fracture of a radius in rats living at 20° C. and 300° C. leads to a greater whole‐body retention by both groups of a tracer dose of 85 Sr injected at the time of fracture, compared to the whole‐body retention found in isothermally housed uninjured controls. A simple small dental drill‐hole lesion of the tibia resulted in an enhanced whole‐body retention of tracer only in rats living at 300° C. There is evidence of skeletal mobilization of calcium on fracture of a bone in rats at 20° C., but not in those at 30° C. However, there were no histologically observable differences in healing of bone lesions between the two groups of rats.